Duo
| Style | Shared poison: Twitch poisons and Cassiopeia fires |
| Difficulty | Medium-High To verify |
| Strong at | Mid game and team fights |
| Weak against | Engages and assassins To verify |
| Patch tier | Pending |
| Win rate | Pending |
Why it works
- Twitch poisons. His W throws a canister that slows and applies deadly venom; his E detonates the accumulated poison.
- Cassiopeia punishes the poisoned. Her E (Twin Fang) deals more damage to poisoned targets and heals her.
- Cassiopeia roots them in place. Her W slows and grounds, and grounded enemies can't use movement abilities.
- Cassiopeia's R. It stuns enemies facing her and slows those with their back turned.
Weak points: Engages and assassins; it depends on coordination between both players. To verify
Powerspikes by level
| Level | What changes | How to play it |
|---|---|---|
| 6 | Cassiopeia's R and Twitch's R for the finish. | Coordinate the play before going in. |
| 11 | Key items: constant poison on the enemy. | Coordinate the play before going in. |
Combo (team fights)
- Twitch: W to apply the poison.
- Cassiopeia: W to ground them.
- Cassiopeia: E on the poisoned.
- Twitch: E for the finish. To verify
Combo mistakes: doing it when the other isn't ready or without vision of the map.
Level 6 protocol
- Cassiopeia: R to stun.
- Twitch: R to shoot from range. To verify
Game plan
| Phase | Goal | Key action |
|---|---|---|
| Start | Farm without giving away health. | Vision and communication. |
| 6-5 | First strong trade. | Cassiopeia's R and Twitch's R for the finish. |
| 6+ | Decisive fights. | Key items: constant poison on the enemy. |
Runes and summoner spells
To verify
| Champion | Main path | Spells |
|---|---|---|
| Cassiopeia | Arcane Comet or Electrocute | Flash + Ignite |
| Twitch | Conqueror or Lethal Tempo | Flash + Heal |
Items, matchups and bans
Pending No patch data. Bans by mechanic (hypotheses to verify): Engages and assassins. Win-rate-based bans will come with Riot API data. To verify
Critical mistakes to avoid
- Wasting Twitch's W without Cassiopeia nearby.
- Cassiopeia without mobility.
- Twitch without camouflage.
How to play against Cassiopeia + Twitch
Kill Cassiopeia or Twitch before they apply the poison. To verify
Frequently asked questions
What does Cassiopeia's E do? It deals more damage to the poisoned and heals her.
Methodology and updates
- Data source: abilities from Data Dragon 16.21.1; own analysis, untested.
- Last review: Pending.
